Compounds and Compound Libraries
- 60.000 compounds at library of FMP, additional hundred thousands of compounds from EU-OPENSCREEN
- Natural product derived synthetic molecules or purified from plants or bacteria
- Synthetic small molecules
- Biologicals (antibodies, aptamers, therapeutic enzymes)
- Peptide drug discovery
High-Throughput Screening
- Large compound library
- Genomic screening: RNAi (C. elegans, mouse and human cell lines), or CRISPR-Cas9 libraries
- Cell-based analysis using automated microscopy, label-free impedance, surface plasmon resonance and kinetic imaging
Development of Cell-Based and Biochemical Assays
- Cellular assays (human primary cells, tumor organoids, tumor cell lines, complex tissue and disease models, phenotypic assays, selected pathological pathways)
- Biochemical assays, e.g. ELISA, peptide-, antibody- or aptamer-based assays
- Binding assays
Biomarker Identification & Validation
- Using human cohorts (e.g. NAKO, pregnancy, renal and cardio diseases, preeclampsia etc.) or patient samples
Services
- Biochemical and cellular assays
- Protein analysis, e.g. LC-MS, Maldi-Tof, HPLC/LC/MS, DigiWest, Luminex, ProteinSimple, ELISA
- Quantitative flow cytometry
- Protein-ligand binding analysis, e.g. surface plasmon resonance, NMR or using biophysical analysis
- Electrophysiology, e.g. ion channel drug discovery, Ca2+ imaging, CiPA assays, MEA-based assays
- Computational drug discovery
