Medicinal Chemistry & Lead Optimization

Medicinal Chemistry

• Development and optimization of various synthesis methods including chemo-enzymatic methods
• Up-scaling from analytical to industrial scale
• Production of APl­
• Production of standards and reference materials
• Production sites with ISO9001 certificate and GMP environment available
• Special expertise in synthesis of peptide, enzymes and aptamers
• Documentation of API synthesis

Hit-to-Lead Optimization

• Drug candidates (small molecules, antibodies, peptides, aptamers, immune & cell therapies) and malaria vaccine candidates
• Chemistry for modification and optimization of hits
• (Stem) cell- based screening assays and stem cell differentiation models
• Structure-based drug design, e.g. with NMR and X-ray crystallography
• Computational drug design
• Iterative cycles to optimize toxicity & PK/PD data