Medicinal Chemistry & Lead Optimization
Medicinal Chemistry
- Development and optimization of various synthesis methods including chemo-enzymatic methods
- Up-scaling from analytical to industrial scale
- Production of APlĀ
- Production of standards and reference materials
- Production sites with ISO9001 certificate and GMP environment available
- Special expertise in synthesis of peptide, enzymes and aptamers
- Documentation of API synthesis
Hit-to-Lead Optimization
- Drug candidates (small molecules, antibodies, peptides, aptamers, immune & cell therapies) and malaria vaccine candidates
- Chemistry for modification and optimization of hits
- (Stem) cell- based screening assays and stem cell differentiation models
- Structure-based drug design, e.g. with NMR and X-ray crystallography
- Computational drug design
- Iterative cycles to optimize toxicity & PK/PD data