Formulation
- Formulation concept studies (Pre-Formulation/Coating, and Feasibility) for agents, therapeutics and vaccines
in-vitro & in-vivo Pharmacokinetics, -dynamics & ADME
- Absorption, Distribution/ Biodistribution, Metabolism, Excretion/ cleareance
- GMP substance testing for pharmaceutical quality control
Molecular Imaging, Experimental Pathology & Histopathology
- Necropsies, Tissue preparation and staining (e.g. Immunohistochemistry)
- Diagnostic services, e.g. Phenotyping or digital pathology
- Tracer Development Services
X-Ray / µCT / X-Ray Fluorescence
- In-vivo soft-tissue imaging
- Functional imaging for the use of stents and catheters
- Scaffold implants investigations (CT) and chemical speciation via XANES
- X-Ray based tumor irradiation and immune system depletion
Animal Facilities
- animal care facility for rodents, african clawed frogs and for larger animals (dogs, cats)
- Large animal imaging facility (pigs)
Further Services
- Development of preclinical studies
- Comprehensive and Contextual Data Review of animal studies
- Regulatory documentation and support
- Consulting & project management of funding proposals
In-vitro Models
- Neurology: cell (and stem cell) based test systems
- Rheumatology: osteoporosis, osteoarthritis & rheumatoid arthritis,
- Ageing including osteoporosis
- Oncology: human tumor cell lines and patient derived 3D cell culture tumor models
- Infection Diseases: murine malaria infection models for liver stage biology and immunology
Toxicology
- Tolerability, Blood chemistry, Haematology, Neurotoxicity and Embryotoxicity
- FDA/EMA-compliant animal and ex vivo tissue studies
Dosage
- Pre-Formulation and Feasibility studies for oral, parental and local drug delivery systems
Ex-Vivo Pharmacokinetics (PK)
- Compound analysis in biological material (e.g. blood, tissue) (epo)
- Murine malaria infection model for both drug and vaccine formulation testing
- Biopsy of dermatological tissues
Analytics, Bio-Analytics
- Maldi-Tof, LC-MS, HPLC/LC/MS
- Mass-Spec/ GMP testing for pharmaceutical quality control
- Flow cytometer (quant.)
MRI & PET/MR & MPI
- Rat Brain imaging - Stem cell labeling
- Cardiovascular tumor imaging
- Physio-metabolic imaging with Ultrahigh-Field MR
- MR elastography
- MPI Spectrometer and in-vivo Scanner
Further Imaging Facilities/Supplies
- Preclinical imaging agents for small animal imaging covering all modalities
- 3D Optical fractionator (size of cell populations) (Charité/ AG Steiner)
- Optical and ultrasound imaging and bioluminescence for tumor analysis
in-vivo and ex-vivo Models
- Oncology: tumor models in rodents - humanized
- Neurology: neurodegenerative diseases and neuro-inflammation in rodents
- Metabolism: Diabetes, dermal absorption & metabolism studies in rats
- Ex-vivo tissue studies